swine origin H1N1 influenza (S-OIV)
aka Pandemic H1N1 09

 
daughter with flu

My daughter getting tested.

 

Vaccine Trials have Begun in Australia

Tamiflu resistant cases

found in Hong Kong, Japan and Denmark

WHO

is changing its reporting guidelines and will no longer regularly report cases. This pandemic has spread more than 4 times faster than usual.

Sanofi-aventis

to donate 100 million doses of pandemic H1N1 vaccine to WHO

Few new cases in Massachusetts as it levels off finally in the U.S.
Seems also to be slowing down in Canada.

Top 6 countries are U.S. Mexico Canada UK Chile Australia which account for 92% of cases.

Half of deaths are due to respiratory failure of otherwise healthy people.

Inuit hit very hard in Canada

 


from the World Health Organization

Data compiled from the CDC and WHO

Worldwide Swine Flu Cases vs time Swine Flue cases U.S. vs time Swine flu in Australia vs time H1N1 Massachusetts

new cases world

new cases u.s.

lines show a weighted average

timelineofFluCases
ISO codes for countries


 

  • Most cases in the World are in the U.S.
  • Most case in the U.S. have been in Wisconsin
  • Most cases are between 5 and 24 years old, rare in those over 65
  • Mortality is highest for those in their 20-30's
  • Starting to take off in Australia and Chile where they are looking to predict next winter's behavior in the Northern Hemisphere
  • On average 4.7 deaths per 1000 reported cases

Data from WHO

Data from WHO

 

 

 

Origins of the novel H1N1 virus
New England Journal of Medicine
In the 1990's human H3N2 combined with avian and swine flus creating a new virus, this then combined with a H1N1 swine to make a H1N2 virus around 10 years ago which recently combined with a Eurasian swine to make the new H1N1 virus

SCIENCE


click the image for full size

The eight segments shown within each virus,represent the following proteins (top to bottom): polymerase PB2, polymerase PB1, polymerase PA, hemagglutinin, nuclear protein, neuraminidase, matrix proteins, and nonstructural proteins.

The polymerases copy the RNA. The hemagglutinin is for getting into a cell and the neuraminidase for getting out.

 


Seasonal Influenza

Why flu strikes in cold weather seasonal data from CDC

Flu infection

The flu is an RNA Virus with a high mutation rate such that it evolves into new quasispecies which can infect someone who has previously had a different version of the virus. The figures below show the global tracking of influenza virus strains by WHO to determine the mix to use for vaccinations.

 

weekly statistics from CDC

Nature Podcast Avian Flu

Antivirals in milk

Flu Drugs

Nova 1918 flu