Michael J. Hearn
Professor and Chair, Department of Chemistry

OFFICE: Science Center 147
TEL: 781-283-3127
E-MAIL: mhearn@wellesley.edu
FAX: 781-283-3642
DEGREES: B.A., Rutgers College; M.S., M.Phil., Ph.D., Yale University


Synthetic Organic Chemistry, Preparation of Tuberculosis Antimicrobials, Near-Infrared Spectroscopy


Teaching Interests and Activities:

My teaching duties usually include strong involvement in Organic Chemistry I and Organic Chemistry II, but I also frequently teach at the Introductory Chemistry level. I teach the Organic Seminar in rotation with the other organic chemists of my department. I especially enjoy seeing the progress of students whom I have met in their first year of chemistry as they go on to study organic. I am keenly interested in working with students to help them to make the intellectual connections between chemistry and their other scientific endeavors. Recently I have been serving as Chair of the Department of Chemistry.

Research Interests and Activities:

I have a long-standing enthusiasm for the synthetic chemistry of organic hydrazines, and most recently this work has centered on the preparation of tuberculostatic derivatives of isonicotinic acid hydrazide (INH). The goal of my work is a better understanding of the antimicrobial effectiveness of these tuberculostatic drugs, through their lipophilic and multifunctional character.. These areas are being explored through cooperative arrangements with the Tuberculosis Antimicrobial Acquisition and Coordinating Facility of the National Institutes of Health and with physician colleagues. Near-infrared spectroscopy provides a powerful tool for the analysis of these compounds and their interactions in solution, but we are also interested in these high-energy vibrational spectra in and of themselves.

Student Projects:

I have been collaborating with a number of student research partners recently. One line of student research work has been an exploration of the synthesis and analysis of lipophilic derivatives of INH. Students have also been investigating the effectiveness of anti-tuberculosis compounds with more than one bacteriostatic site per molecule of drug. Another area of student research has been on the uses of near-infrared spectroscopy to estimate reaction rates of INH.

Other Professional Interests and Activities:

I enjoy working as associate editor of the journal Organic Preparations and Procedures International. I served as the secretary of the Northeastern Section of the American Chemical Society for many years and have recently concluded my term as its Chair, now assuming the office of National Councilor. I work to support the Section's educational activities and its attempts to broaden its diversity among groups traditionally under-represented in chemistry. I take a strong interest in the educational activities of groups dedicated to the advancement of vibrational spectroscopy, such as the Council on Near-Infrared Spectroscopy and the Coblentz Society. I am a volunteer in the Speaker's Bureau for the Council on Undergraduate Research.

Additional Interests and Activities:

I enjoy hiking, travel and cinema, especially the films of von Stroheim, Bergman and Kurosawa.





William F. Coleman wcoleman@wellesley.edu
Dept. of Chemistry
Date Created: Feb 4, 1999
Last Modified: Feb 4, 1999
Expires: Aug 1, 2000